Is there sufficient evidence to repeal three decades of clinical research on chronic hepatitis C?

Is there sufficient evidence to recommend antiviral therapy in hepatitis C?

While patients with chronic hepatitis C virus (HCV) infection are treated in order to prevent liver-related morbidity and mortality, we rely on sustained virological response (SVR) as a virological biomarker to evaluate treatment efficacy in both clinical practice as well as in drug development. However, conclusive evidence for the clinical benefit of antiviral therapy or validity of SVR as sur...

the optimal dose of ribavirin for chronic hepatitis c: from literature evidence to clinical practice

Heavy Metals Levels in Plastics Housing of Televisions: Is there a changing trend across three decades (1980-2000)?

Background: This study investigated the concentration of some heavy metals in plastic housing of televisions produced over three decade (1980-2000) with the aim of providing information and comparing the trend in the concentration of these metals. Methods: The heavy metal concentrations were determined by atomic absorption spectroscopy after acid digestion using a 1:1 mixture of sulphuric an...

commentary on: the optimal dose of ribavirin for chronic hepatitis c: from literature evidence to clinical practice

The optimal dose of ribavirin for chronic hepatitis C: From literature evidence to clinical practice

Approximately 170 million people worldwide are chronically infected by hepatitis C virus (HCV), which can result in progressive hepatic injury and fibrosis, culminating in cirrhosis and end-stage liver disease. The benchmark therapy for untreated HCV patients is a combination of pegylated interferon-alpha (PEG-IFN) and ribavirin (RBV). Several studies have suggested several potential new approa...